The syllabus for TNPSC Group II and IIA exams includes topics such as General Studies, General English, and General Tamil. General Studies covers subjects like History, Geography, Economics, Science, Current Affairs, and Polity. It also includes questions on Indian National Movement and Aptitude & Mental Ability Test. The General English section focuses on grammar, literature, and language skills. Similarly, the General Tamil section tests candidates' proficiency in the Tamil language. Both Group II and IIA exams emphasize knowledge relevant to administrative roles and public service in Tamil Nadu.

Additional subjects specific to certain posts include Law for roles like Deputy Commercial Tax Officer, and Sociology or Psychology for Probation Officer. Technical knowledge relevant to administrative roles in various fields such as Handloom Technology, Textile Processing, and Computer Applications is also tested for specific positions. Overall, these exams aim to evaluate candidates' knowledge and skills necessary for effective performance in administrative and managerial roles within the Tamil Nadu government.